Organ Transplantation Research Today is a free monthly online journal that collates and summarizes the latest research about Organ Transplantation, including details on risks, prognosis, procedure, surgery.

Vascularized bone allotransplantation: current state and implications for future reconstructive surgery.

Bishop AT, Pelzer M

Division of Hand Surgery, Department of Orthopedic Surgery, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, MN 55905, USA. bishop.allen@mayo.edu

This article focuses on current advances in musculoskeletal tissue allotransplantation, including strategies for maintaining tissue viability in the face of histocompatibility mismatch and resulting acute and chronic rejection responses. In particular, it introduces a novel concept developed in the authors' laboratory and currently under evaluation that may obviate the problem of chronic rejection. The authors have used therapeutic angiogenesis to develop a host-derived neoangiogenic circulation that maintains blood flow regardless of rejection. The replacement of the allogeneic vessels together with bone remodeling from host-derived cells eventually may largely replace the allogeneic osteocytes and bone with native bone.

Published 5 December 2006 in Orthop Clin North Am, 38(1): 109-22, vii.
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