Organ Transplantation Research Today is a free monthly online journal that collates and summarizes the latest research about Organ Transplantation, including details on risks, prognosis, procedure, surgery.

Redo ureteroneocystostomy using an extravesical approach in pediatric renal transplant patients with reflux: a retrospective analysis and description of technique.

Krishnan A, Swana H, Mathias R, Baskin LS

Department of Urology, Divisions of Pediatric Urology and Nephrology, University of California at San Francisco, San Francisco, California, USA.

PURPOSE: Vesicoureteral reflux and pyelonephritis following transplantation may significantly contribute to renal damage and premature graft loss. We report our retrospective experience with redo ureteral reimplantation of refluxing pediatric renal transplants and describe our surgical technique. MATERIALS AND METHODS: We identified 20 children with a diagnosis of symptomatic post-transplant vesicoureteral reflux, of whom 16 underwent redo ureteral reimplantation. Patient characteristics including etiology of end stage renal disease, presenting symptoms, serum creatinine and postoperative followup were documented. The presence or absence of lower urinary tract dysfunction was documented and values between the 2 groups were analyzed for significance. RESULTS: All 20 patients presented after assessment for a febrile urinary tract infection, and 35% had concurrent lower urinary tract dysfunction. Median interval between transplantation and vesicoureteral reflux diagnosis was 1.3 years, and mean vesicoureteral reflux grade was 3.2. Patients with lower urinary tract dysfunction presented significantly earlier and had a higher postoperative serum creatinine than those without lower urinary tract dysfunction (1.1 vs 1.7 years, p = 0.048). Redo reimplantation was performed in 94% of patients using an extravesical approach with ureteral stent placement. Seven of 16 patients underwent followup voiding cystourethrogram, with 5 demonstrating resolution and 2, both with lower urinary tract dysfunction, exhibiting persistent vesicoureteral reflux. At a mean followup of 3.6 years 25% of patients experienced recurrent pyelonephritis, while 75% were asymptomatic. One instance of anastomotic stricture occurred in a patient with lower urinary tract dysfunction. CONCLUSIONS: Effective repair of post-transplantation vesicoureteral reflux can be performed using an extravesical technique, facilitated by preoperative ureteral stent placement. Patients with lower urinary tract dysfunction are likely to present earlier after transplantation than those without lower urinary tract dysfunction, and may have an increased risk of persistent vesicoureteral reflux and renal damage despite surgical correction.

Published 5 September 2006 in J Urol, 176(4): 1582-7; discussion 1587.
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