Organ Transplantation Research Today is a free monthly online journal that collates and summarizes the latest research about Organ Transplantation, including details on risks, prognosis, procedure, surgery.

Suppression of cell-mediated immunity by a donor-transmitted lymphocytic choriomeningitis virus in a kidney transplant recipient.

Gautam A, Fischer SA, Yango AF, Gohh RY, Morrissey PE, Monaco AP

Division of Organ Transplantation, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA. agautam@lifespan.org

Infection with lymphocytic choriomeningitis virus (LCMV) in rodents, the primary host, is known to cause suppression of cell-mediated immunity. Serial determinations using a functional cell-mediated immune assay in a kidney transplant recipient with donor-transmitted LCMV also suggested profound suppression of cellular immunity. This suppression persisted in spite of reduction of immunosuppression. With the clearance of the virus there was reconstitution of the cellular immune response.

Published 7 November 2007 in Transpl Infect Dis, 9(4): 339-42.
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