Organ Transplantation Research Today is a free monthly online journal that collates and summarizes the latest research about Organ Transplantation, including details on risks, prognosis, procedure, surgery.

Spontaneous tooth eruption after alveolar cleft osteoplasty using tissue-engineered bone: a case report.

Pradel W, Tausche E, Gollogly J, Lauer G

Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, Dresden, Germany.

To bridge the cleft in the alveolar bone and to allow for physiologic eruption of the canine teeth, alveolar bone grafting is often necessary in patients with cleft lips and palates. Instead of autogenous bone, biomaterial seeded with autogenous osteogenic cells has found some clinical application. However, so far no real functional proof has been available to demonstrate that this technique also allows further physiologic features such as tooth eruption to occur. This report describes the results of grafting tissue-engineered bone into the alveolar cleft of a 10-year-old boy. Immediate postoperative healing was uneventful. Eight months after grafting, erupting teeth had moved into the newly formed bone. Eighteen months postoperatively at the site where the tissue-engineered graft had been inserted, the canine had erupted spontaneously in its proper place. The data suggest that tissue-engineered bone can lead to the ossification of the alveolar cleft and allow for physiologic spontaneous tooth eruption.

Published 10 March 2008 in Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 105(4): 440-4.
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